Paula
Well, I was on about 2 1/2 to 3 mg of Pred when I decided to lose somw weight and while it took quite awhile I did it. I also lost weight about 2 or 3 years ago while on larger doses of pred..think I lost about 16 #..but gained most of it back because I ate too much junk and still did not feel up to exercising at all. I have kept off the weight I lost so far this time and yes, it is possible altho I think on large doses it might not be possible to lose much. I think I was on about 10mg. when I lost the weight a few years back..I feel some better now and I know it's better for my joints, knees and blood pressure so it was worth doing.